This randomized cross-over pilot trial with 40 CED patients currently in remission showed a significant beneficial effect of high-dose oral thiamine on chronic fatigue as compared to placebo with only few and mild side effects.
Antibiotic treatment did not affect length of hospital stay, rates of adverse events and readmission rates after 7 or 30 days as compared to placebo in a randomized placebo-controlled trial comprising 180 patients. These results provide strong evidence that antibiotic therapy may be safely omitted in patients with uncomplicated diverticulitis.
A national analysis in the UK revealed that endoscopic activity in spring 2020 was reduced to 12% of pre-Covid-19 levels and resulted in a decrease of tumor diagnoses by 58%.
In recent years, human albumin substitution in patients with advanced cirrhosis has been the subject of controversy. A current randomized study in patients who were hospitalized with decompensated cirrhosis showed a negative result in this regard: Albumin infusions to increase the albumin level to a target of ≥ 3 g/dl were not superior to the current standard treatment.
A recent cohort study confirms the high benefits of metformin in patients with NASH, type 2 diabetes and Child A cirrhosis. Especially in patients with increased hemoglobin A1c, metformin significantly reduced the risk of death, decompensation of cirrhosis and hepatocellular carcinoma.
A current, highly anticipated vaccination study on the prophylactic vaccination against HCV using a viral vector vaccine with a prime boost regimen showed that this vaccination regimen induced T-cell responses against HCV and decreased HCV viremia in infected people. Unfortunately, however, the vaccination regime was unable to prevent chronic HCV infection.
Oesophagus Stomach Duodenum
The tachykinin receptor 1 antagonist tradipitant resulted in a statistically and clinically meaningful improvement in nausea and vomiting as compared to placebo.
Novel oral anticoagulants do not alter the outcomes of upper GI bleeding as compared to vitamin K antagonists in a prospective nationwide study from France. Comorbidities and occurrence of bleeding during hospitalization were the most important risk factors associated with adverse outcomes.
Analysis of the global GLOBOCAN initiative revealed increasing incidence and mortality trends in pancreatic cancer, especially in women and populations 50 years or older, but also in younger individuals.