Revista Gastroenterología

August – September 2021



Non-alcoholic fatty liver disease (NAFLD).

A nationwide Swedish cohort study shows that all histological NAFLD stages are associated with significantly increased overall mortality with the risk increasing with stage (simple steatosis – steatohepatitis – fibrosis – cirrhosis). Most of this excess mortality was due to extrahepatic cancer and cirrhosis, while the contributions from cardiovascular disease and hepatocellular carcinoma were lower.

Wilson disease.

Diagnosis of Wilson disease based on laboratory or genetic parameters is often difficult. A current study shows that the determination of ATP7B peptides is highly effective in the diagnosis of Wilson disease (sensitivity 91.2%, specificity 98.1%, positive predictive value 98%, negative predictive value 91.5%). This also applied to Wilson disease patients with normal ceruloplasmin levels or ambiguous genetic results.

Chronic hepatitis B virus (HBV) infection.

A recent South Korean study reveals that risks of hepatocellular carcinoma (HCC) and clinical events do not differ significantly between spontaneous and therapy-induced HBsAg seroclearance. However, the annual HCC risk exceeds the recommended cut-off for HCC surveillance even after HBsAg seroclearance, suggesting that continued HCC surveillance is required. Future studies need to clarify whether these Asian study results also apply to e.g. European cohorts.

Oesophagus Stomach Duodenum

Novel therapy for celiac disease (1).

In a proof-of-concept study, immune modulating gliadin nanoparticles (TAK-101) were well tolerated and prevented gluten-induced immune activation in patients with celiac disease. These findings suggest that antigen-specific tolerance was induced indicating that TAK-101 may represent a promising approach to treat celiac disease.




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