Revista Gastroenterología

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Bowel

Liver

Non-alcoholic fatty liver disease (NAFLD):

The prevalence of NAFLD in pregnancy has nearly tripled in the last decade and is independently associated with hypertensive complications, postpartum hemorrhage and preterm birth. NAFLD should thus be considered a high-risk obstetric condition.

Primary biliary cholangitis (PBC):

A large retrospective cohort study analyzed preventive treatment with ursodeoxycholic acid (UDCA) in patients who received liver transplantation for PBC. Preventive UDCA treatment was associated with a reduced risk of disease recurrence, graft loss, and death. A regimen combining cyclosporine and preventive UDCA was associated with the lowest risk of PBC recurrence and mortality.

Autoimmune hepatitis (AIH):

A recent retrospective cohort study indicates that normalization of serum immunoglobulin G (IgG) levels is an independent predictor for transplant-free survival. Thus, normalization of IgG levels should be a treatment target along with normalization of transaminases.

Oesophagus Stomach Duodenum

Novel approach to treat HER-2-positive gastric cancer:

Therapy with trastuzumab deruxtecan, a conjugate of an anti-HER2 antibody and a topoisomerase I inhibitor, resulted in improved objective response rates and overall survival, as compared to conventional chemotherapy in a phase II trial enrolling Asian patients with advanced tumors. Myelosuppression and interstitial lung disease were the notable side effects.

Pancreas

ERCP for patients with acute severe biliary pancreatitis:

Results of a randomized trial indicate that urgent ERCP with sphincterotomy did not reduce a composite end point of major complications or mortality as compared to conservative treatment in patients with predicted severe biliary pancreatitis. These findings suggest that ERCP should be performed only in patients with concomitant cholangitis or persistent cholestasis.

Ell y el riesgo de contagio por COVID-19

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