Revista Gastroenterología

December 2020


Long-term follow-up of the LIR!C trial (laparoscopic ileocecal resection vs. infliximab for terminal ileitis in Crohn’s disease)

Long-term analyses of patients enclosed in the LIR!C trial support the notion that laparoscopic ileocecal resection is a reasonable treatment option for ileocecal Crohn’s disease. A considerable proportion of patients who underwent surgery did not require additional Crohn’s disease-related medications or only primary prophylaxis of recurrence. In contrast, most of the patients treated with infliximab required long-term therapy with biologics or escalation of therapies and approx. half of the patients ultimately required surgery.

Infectious cause of microscopic colitis:

Results of a population-based cohort study in Denmark revealed a high risk of microscopic colitis following infection with Campylobacter concisus in stools, suggesting that C. concisus may be involved in the pathogenesis of this disease.


COVID-19 and cirrhosis

A recent retrospective study suggests that patients with cirrhosis and COVID-19 have about twice the mortality rate than patients with cirrhosis and bacterial infection or COVID-19 patients without cirrhosis.

Acute liver failure in pregnancy

In a current database evaluation, approx. 2% of acute liver failure cases occurred during pregnancy. Pregnancy-associated liver diseases (acute fatty liver of pregnancy or HELLP syndrome with hemolysis, elevated liver enzymes and low platelets) caused only about half of the cases. Prognosis of acute liver failure in pregnancy is still poor: In the current analysis, 11 of 70 patients (16%) required liver transplantation and 8 patients (11%) died.

Non-alcoholic fatty liver disease (NAFLD)

A recent retrospective cohort study confirms that patients with hepatic steatosis and persistently normal alanine aminotransferase do not have an increased risk of liver cirrhosis and hepatocellular carcinoma. Thus, these patients probably do not require close monitoring for liver outcomes.

Oesophagus Stomach Duodenum

Effects of time-restricted eating on weight loss

Time-restricted eating, in the absence of other interventions, was not more effective in weight loss than conventional eating (3 structured meals throughout the day) in a randomized clinical trial involving 116 participants with overweight and obesity.


Current Falk literature:




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