Wednesday, October 20, 2021

Revista Gastroenterología

July 2020

Bowel

Risk of colorectal cancer incidence and mortality after polypectomy

Patients with any polyps in a largely screening-naive population of Sweden had a higher colorectal cancer incidence as compared to individuals from the general population. Moreover, patients with sessile serrated polyps, tubulovillous or villous adenomas had a higher colorectal cancer mortality.

Liver

Liver involvement in COVID-19

In a current study, more than one third of patients admitted to the hospital with SARS-CoV-2 infection had abnormal liver enzymes. This was associated with longer hospital stay. In addition, treatment with lopinavir/ritonavir was associated with increased liver enzymes; these drugs should be given with caution.

Hepatocellular carcinoma (HCC)

In patients with unresectable HCC, atezolizumab combined with bevacizumab resulted in better overall and progression­free survival outcomes than sorafenib. In this current phase 3 trial, 12 months overall survival was 55% with sorafenib and 67% with atezolizumab-bevacizumab. Grad 3 and 4 adverse events occurred with the same frequency with sorafenib and atezolizumab-bevacizumab, respectively.

Acute intermittent porphyria

In a phase 3 trial, monthly application of givosiran, an RNA interference therapy, reduced the frequency of acute attacks by 74%. In addition, the need for hemin as well as daily pain scores decreased.

Oesophagus Stomach Duodenum

Pancreas

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