The most important facts summarized: Is there anything known about the interactions between genetic and environmental risk factors?A gene and environment interaction is very likelyA number of gene variants are associated with EoE, e.g. variations in the Calpain-14-or TGF-β geneDo you have an explanation for the existence of geographical EoE-hotspots?The presence in western countries like the US seems to be associated with air pollution and large commercial farming enterprisesIt is assumed that environmental factors harm the esophageal barrier and thereby expose the esophagus to allergenic triggersThe peak prevalence of EoE...
A tight control strategy used in the CALM trial, which is based on clinical parameters as well as biomarkers of inflammation, is cost-effective as compared to conventional therapy. The economic value of tight control therapy increased when costs related to work productivity are incorporated.
Results of a randomized trial reveal that FMT may be an effective treatment for IBS patients. Utilizing a well-defined donor with normal intestinal diversity and a favorable microbial signature appears to be essential for successful FMT. Moreover, response to therapy increases with FMT dose.
A model based on clinical parameters and the protein markers β2 microglobulin and CD40 can predict future renal deterioration early after liver transplantation. This model may thus help in the early selection of recipients for proactive renal sparing strategies.
A current prospective register study demonstrates that this group of rare genetic disorders is associated with a high disease burden (inpatient treatment e.g. with hemin) and diminished quality of life (chronic symptoms impairing day-to-day functioning). These results highlight the need for novel therapies.
Improvement of fibrosis stage is a common end point in clinical trials. A current systematic review and meta-analysis demonstrates that the fibrosis stage is associated with risk of mortality and liver-related morbidity in patients with NAFLD and NASH and thus confirms the validity of this surrogate marker as end point in clinical trials.
Oesophagus Stomach Duodenum
First-line dual therapy with vonoprazan and low-dose amoxicillin for 7 days provided acceptable eradication rates in Japanese patients similar to vonoprazan-based triple therapy in regions with high clarithromycin resistance.
In patients with high risk for future bleeding and death, endoscopy performed within 6 hours after gastroenterological consultation did not result in reduced mortality or recurrent bleeding rates as compared to endoscopy performed within 6–24 hours.
A meta-analysis of observational studies did not find an association between PPI therapy and increased risk of dementia including Alzheimer dementia.
Real-world data from the US suggest that molecular tumor profiling and subsequent targeted therapies can have a substantial effect on patient survival.
Current Falk literature:
Crohn’s Disease and Ulcerative Colitis in Children and Adolescents Author: M. Claasen in collaboration with: S. Buderus, J. de Laffolie,...Read more