Wednesday, October 20, 2021

Revista Gastroenterología

June 2020

Who get’s EoE? – Part II: Genetic & geographical risk factors

The most important facts summarized: Is there anything known about the interactions between genetic and environmental risk factors?A gene and environment interaction is very likelyA number of gene variants are associated with EoE, e.g. variations in the Calpain-14-or TGF-β geneDo you have an explanation for the existence of geographical EoE-hotspots?The presence in western countries like the US seems to be associated with air pollution and large commercial farming enterprisesIt is assumed that environmental factors harm the esophageal barrier and thereby expose the esophagus to allergenic triggersThe peak prevalence of EoE...

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Bowel

Cost effectivity of tight control for Crohn’s disease:

A tight control strategy used in the CALM trial, which is based on clinical parameters as well as biomarkers of inflammation, is cost-effective as compared to conventional therapy. The economic value of tight control therapy increased when costs related to work productivity are incorporated.

Digestive symptoms in COVID-19 patients:

Results of a cross-sectional cohort study from China suggest that gastrointestinal symptoms, in particular lack of appetite and diarrhea, occur in up to half of the patients with COVID-19 and may be present even in the absence of respiratory symptoms.

Liver

Renal outcomes after liver transplantation:

A model based on clinical parameters and the protein markers β2 microglobulin and CD40 can predict future renal deterioration early after liver transplantation. This model may thus help in the early selection of recipients for proactive renal sparing strategies.

Acute hepatic porphyria

A current prospective register study demonstrates that this group of rare genetic disorders is associated with a high disease burden (inpatient treatment e.g. with hemin) and diminished quality of life (chronic symptoms impairing day-to-day functioning). These results highlight the need for novel therapies.

Oesophagus Stomach Duodenum

Timing of endoscopy for upper gastrointestinal bleeding

In patients with high risk for future bleeding and death, endoscopy performed within 6 hours after gastroenterological consultation did not result in reduced mortality or recurrent bleeding rates as compared to endoscopy performed within 6–24 hours.

Pancreas

Current Falk literature:

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