A simple ultrasound activity index consisting of bowel thickness and color Doppler was constructed and validated and correlated well with endoscopic disease activity.
In a randomized trial of patients with refractory IBS with predominant bloating, FMT relieved symptoms compared to placebo (transfer of autologous stool). The effects decreased after 1 year and could be restored by a second FMT in patients with prior response. Clinical response was also associated with composition of the fecal microbiota which may serve as biomarker for future response to therapy.
A new online tool substantially improves postoperative mortality predictions in patients with cirrhosis. Predictors include age, preoperative albumin, platelet count, bilirubin, surgery category, emergency indication, fatty liver disease, ASA (American Society of Anesthesiologists) classification, and obesity. (www.vocalpennscore.com)
A recent double-blind, randomized, placebo-controlled trial indicates that bezafibrat (400 mg/day) may substantially improve moderate-to-severe pruritus in these conditions.
The simplified criteria for the diagnosis of AIH include immunofluorescence testing of antinuclear and smooth muscle autoantibodies (ANA and SMA) on rodent tissue sections. A current study demonstrates that at adjusted cut-offs, both ANA immunofluorescence testing using human epithelioma-2 cells and ELISA-based autoantibody evaluation for ANA and SMA are potential alternatives.
Oesophagus Stomach Duodenum
FMT of autologous stool collected during the weight-loss phase and administered during the weight gain phase preserved weight loss and glycemic control and was associated with specific microbiome signatures. This approach was particularly successful using a high-polyphenol, green plant-based or Mankai diet.
Population-based eradication of H. pylori significantly reduced gastric cancer incidence in a high-risk cohort in Taiwan without causing significant side effects. However, there was no impact on tumor-associated mortality, but the follow-up may not have been sufficiently long to address this question.
There was no benefit from PPI therapy in patients with persistent throat symptoms in a randomized placebo-controlled trial.
Results of a multicenter retrospective cohort study suggest that endoscopic transluminal drainage results in clinical success in the long term. However, the majority of patients required additional re-interventions for clinically relevant iatrogenic infections.