Revista Gastroenterología

November 2020

Bowel

Diet and risk of inflammatory bowel disease:

Results of 2 prospective cohort trials from Sweden with more than 86.000 patients reveal that adherence to a Mediterranean diet is associated with a reduced risk of primary manifestation of Crohn’s disease at an age over 45 years. Mediterranean diet was not associated with the risk to develop ulcerative colitis.

Prognosis of Crohn’s disease:

An analysis of follow-up data from the CALM study, induction of deep remission in early, moderate to severe Crohn’s disease was associated with decreased risk of disease progression over a median time of 3 years, irrespective of disease management by tight control or conventional therapy within the CALM trial.

Liver

Acute liver injury in COVID-19:

Acute liver injury is common in patients who test positive for SARS-CoV-2, but is most often mild. However, 6.4% of patients develop severe liver injury (alanine aminotransferase > 5 times the upper limit of normal); in these patients, severe disease course and high mortality should be anticipated.

Primary sclerosing cholangitis (PSC):

In a 10-year, nationwide study, patients with PSC and inflammatory bowel disease (IBD) had increased risks of colorectal cancer (CRC), hepatopancreatobiliary cancers, and death compared to patients with IBD alone. In the PSC-IBD group, diagnosis of IBD at age < 40 years was associated with greater risks of CRC and all-cause mortality.

Hepatitis B virus (HBV) and hepatic steatosis:

In patients with virologically quiescent chronic HBV infection, presence of hepatic steatosis is associated with a higher risk of fibrosis progression but, paradoxically, a 3-fold increase in HBsAg seroclearance rate (“functional cure”). Steatosis measurements by transient elastography thus have predictive value in patients with virologically quiescent chronic HBV infection.

Oesophagus Stomach Duodenum

Pancreas

Current Falk literature:

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