Revista Gastroenterología

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EoE – Recent Developments in Diagnosis & Treatment: Dietary treatment: chances and limitations

The most important facts summarized: • Dietary therapy can be beneficial for a certain group of EoE-patients • The best results are achieved with an amino-acid-based elemental diet, which, however, is hard to follow in the long run • More practical is an elimination diet with the exclusion of up to six food groups • A targeted elimination of foods after allergy testing shows the least satisfying results • Dr. Lucendo recommends a step-wise and endoscopically monitored step-up elimination diet where initially two food groups are removed, followed by four...

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Biomarker for Crohn’s disease:

An observational genome-wide association study found a highly significant association between HLA-DQA1*05 and the development of antibodies against anti-TNF agents. Testing for this allele may therefore be useful to predict patient outcomes and to select anti-TNF and combination therapies.


Hepatocellular carcinoma (HCC):

Survival in patients with HCC has improved significantly over the past 20 years. Screening programs are likely to be responsible for this development, since these lead to diagnosis in earlier tumor stages and thus allow better treatment options. However, survival in patients with metastasis when diagnosed has not improved.

Primary sclerosing cholangitis (PSC):

The risk estimate tool “PREsTo” accurately predicts hepatic decompensation (HD) in PSC and exceeds the performance among other widely available, non-invasive prognostic scoring systems. It consists of 9 variables: bilirubin, albumin, alkaline phosphatase, platelets, aspartate aminotransferase (AST), hemoglobin, sodium, patient age, and number of years since PSC was diagnosed.

Chronic hepatitis B and non-alcoholic steatohepatitis (NASH):

A current cohort study confirms the negative impact of an additional NASH on the course of chronic hepatitis B. Almost every 5. patient with chronic hepatitis B also has a NASH; these patients have a significantly increased risk of advanced fibrosis, hepatocellular carcinoma and death.


Celiac disease autoimmunity in adults:

Analysis of serum samples collected from a community hospital over 8.8 years reveals that less than 1% of adults with negative tissue transglutaminase antibodies (tTGA) develop such antibodies over time. Among persons with positive tTGA (celiac disease autoimmunity), less than 20% develop celiac disease over time.


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